Ss a ro is an extractable nuclear antigen ena composed of protein antigens of 52 kd and 60 kd combined with cytoplasmic rna species.
Ssa antibody normal range.
Sjogren s antibodies ss a ss b sjögren s antibodies ss b is detected in approximately 15 of patients with sjögren s syndrome.
Anti ssa can be found in up to 60 of people who are confirmed to have lupus.
Anti ro levels may be elevated in the following conditions.
Ss a ro antibodies occur in patients with several different connective tissue diseases including sjogren syndrome an autoimmune disease that involves primarily the salivary and lachrymal glands up to 90 of cases.
The presence of both antibodies ss a and ss b strengthen the diagnosis of sjögren s syndrome and conveys prognostic information.
Sjögren s antibody ss b is present only if sjögren s antibody ss a is also detected.
The reference range of anti ro antibodies is negative.
In some regions however only 1 in 4 people with lupus will have a positive test result for this antibody.
Ss a ro is composed of protein antigens of 52 kd and 60 kd combined with cytoplasmic rna species.
Lupus erythematosus le 40 60 of.
Anti ss a and anti ss b are found in virtually all children with neonatal lupus.
Another condition called sjorgen s syndrome is also known to produce positive test results in up to 70 of people.
60 70 of cases systemic lupus erythematosus sle.
Anti ssa plus anti la ssb is associated with the following factors.
Patients with ss a may also have antibodies to cardiolipin lupus anticoagulant and clinical thromboses.
A positive anti ro result is revealed and known by a speckled appearance under immune fluorescence with ultraviolet light.
Ss a ro ss b la rnp and sm are autoantigens commonly referred to as extractable nuclear antigens ena.
Ss a ro antibodies are associated with childhood le neonatal le and with congenital heart block in infants born to mothers with le 1 2 ss a ro antibodies have also been reported to be associated with features of extraglandular inflammation in patients with le including vasculitis purpura cytopenias and adenopathy.
This has been termed antiphospholipid antibody syndrome.
Antibodies to ena are common in patients with connective tissue diseases systemic rheumatic diseases.
Both anti ssa and anti ssa are usually absent in secondary sjögren s syndrome.
The reference range of anti ro antibodies is negative.
When anti ssa levels are elevated in sle it is often in antinuclear antibody ana negative lupus.
Age older than 50 years.
Antibodies to ss a are also associated with hla loci dr3 and dr2 and with hereditary deficiency of c2.
Anti ro antibodies also known as anti ssa antibodies are associated with sjögren syndrome.
Ss a ro antibodies occur in patients with several different connective tissue.
Ss b la antibodies are found primarily in patients with sjogren syndrome or le where they occur with frequencies of approximately 60 and 15 respectively 1 2 ss b la antibodies occur only infrequently in the absence of ss a ro antibodies.
