Ssa Antibody Reference Range

Ss a ro ss b la rnp and sm are autoantigens commonly referred to as extractable nuclear antigens ena.

Ssa antibody reference range.

This has been termed antiphospholipid antibody syndrome. Ss b la antibodies are found primarily in patients with sjogren syndrome or le where they occur with frequencies of approximately 60 and 15 respectively 1 2 ss b la antibodies occur only infrequently in the absence of ss a ro antibodies. The reference range of anti ro antibodies is negative. Anti ss a and anti ss b are found in virtually all children with neonatal lupus.

The presence of both antibodies ss a and ss b strengthen the diagnosis of sjögren s syndrome and conveys prognostic information. Anti ro antibodies also known as anti ssa antibodies are associated with sjögren syndrome. The reference range of anti ro antibodies is negative. Sjögren s antibody ss b is present only if sjögren s antibody ss a is also detected.

Ss a ro antibodies occur in patients with several different connective tissue diseases including sjogren syndrome an autoimmune disease that involves primarily the salivary and lachrymal glands up to 90 of cases. Sjogren s antibodies ss a ss b sjögren s antibodies ss b is detected in approximately 15 of patients with sjögren s syndrome. Antibodies to ss a are also associated with hla loci dr3 and dr2 and with hereditary deficiency of c2. A positive anti ro result is revealed and known by a speckled appearance under immune fluorescence with ultraviolet light.

60 70 of cases systemic lupus erythematosus sle. 25 of cases both anti ro ssa and. Lupus erythematosus le 40 60 of. Ss a ro antibodies occur in patients with several different connective tissue.

Patients with ss a may also have antibodies to cardiolipin lupus anticoagulant and clinical thromboses. Antibodies to ena are common in patients with connective tissue diseases systemic rheumatic diseases. Ss a ro antibodies are associated with childhood le neonatal le and with congenital heart block in infants born to mothers with le 1 2 ss a ro antibodies have also been reported to be associated with features of extraglandular inflammation in patients with le including vasculitis purpura cytopenias and adenopathy. Ss b la is composed of a 48 kd protein combined with rna species.